How to make "good use" of a layout plugin like Isotope in GetSimple?

[shawn_a]

Depends, you can simply use a gallery plugin to output a list and target it with jquery to reformat it.

Or for content, you could use a single page for all your content, or write a component that grabs specific pages by tag or whatnot, and add that component to your template to grid it.

You really have to have a design of what you want to do to figure out how to break it down.